IN SILICO ANALYSIS OF CROSS-SPECIES SEQUENCE VARIABILITY IN HOST INTERFERON ANTIVIRAL PATHWAY PROTEINS AND SARS-COV-2 SUSCEPTIBILITY

Abstract The interferon (IFN) signaling pathway plays a crucial role in the innate immune response against viral infections, including SARS-CoV-2. However, host susceptibility to SARS-CoV-2 varies across species, potentially due to differences in key antiviral pathway proteins. This study employs in silico analysis to examine sequence variability

Abstract Alternative RNA splicing is a crucial post-transcriptional mechanism that increases transcript diversity and regulates gene expression. In the heart, precise splicing control is essential for maintaining normal cardiac function. Dysregulation of alternative splicing has been implicated in various cardiac diseases, including dilated cardio